Metabolic dysfunction in diabetic cardiomyopathy
نویسندگان
چکیده
منابع مشابه
Metabolic remodelling in diabetic cardiomyopathy
Diabetes is a risk factor for heart failure and cardiovascular mortality with specific changes to myocardial metabolism, energetics, structure, and function. The gradual impairment of insulin production and signalling in diabetes is associated with elevated plasma fatty acids and increased myocardial free fatty acid uptake and activation of the transcription factor PPARα. The increased free fat...
متن کاملMetabolic and Biochemical Stressors in Diabetic Cardiomyopathy
Diabetic cardiomyopathy (DCM) or diabetes-induced cardiac dysfunction is a direct consequence of uncontrolled metabolic syndrome and is widespread in US population and worldwide. Despite of the heterogeneous and distinct features of DCM, the clinical relevance of DCM is now becoming established. DCM progresses to pathological cardiac remodeling with the higher risk of heart attack and subsequen...
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OBJECTIVE: We aimed to evaluate association between thyroid dysfunction, and lipid profile and glycated hemoglobin in type 2 diabetic patients. MATERIALS AND METHODS: This cross-sectional study was carried out in type 2 diabetic patients who referred to Yazd Diabetes Research Center. A total of 1200 type 2 diabetic patients who had thyroid dysfunction according to clinical examinations and lab...
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BACKGROUND In the diabetic heart the β-adrenergic response is altered partly by down-regulation of the β1-adrenoceptor, reducing its positive inotropic effect and up-regulation of the β3-adrenoceptor, increasing its negative inotropic effect. Statins have clinical benefits on morbidity and mortality in diabetic patients which are attributed to their "pleiotropic" effects. The objective of our s...
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Diabetic cardiomyopathy is the leading cause of heart failure among diabetic patients, and mitochondrial dysfunction has been implicated as an underlying cause in the pathogenesis. Cardiac mitochondria consist of two spatially, functionally, and morphologically distinct subpopulations, termed subsarcolemmal mitochondria (SSM) and interfibrillar mitochondria (IFM). SSM are situated beneath the p...
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ژورنال
عنوان ژورنال: Heart Failure Reviews
سال: 2013
ISSN: 1382-4147,1573-7322
DOI: 10.1007/s10741-013-9377-8